Both escaped injury. They were awakened early Sunday by their dog in time to escape the blaze.
"We're great," Barrymore, a star of "Charlie's Angels," told reporters at the scene.
"Other than the fact that the home burned down," Green added.
Their dog, Flossie, woke them up around 3:30 a.m. when she barked and "literally banged on their bedroom door," said Eddie Michaels, Barrymore's spokesman.
It took firefighters about an hour to douse the flames.
Firefighters estimated damage at $700,000 in the two-story, 3,500-square-foot home north of Beverly Hills.
Michaels, however, said: "The house is totaled."
The cause of the blaze was under investigation.